What is Proton Therapy

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Clinical Trials

Clinical Trials

Always Researching. Always Advancing.

The medical community continues to conduct research studies on proton therapy. SCCA and other academic medical centers are supporting many ongoing clinical trials to expand our knowledge of the most beneficial applications of proton therapy in treating cancer.

Since proton therapy was approved by the U.S. Food and Drug Administration to treat patients in 1988, the medical community has continued to conduct research on the use of protons in treating different types of cancer through clinical trials. Over the years, many patients have volunteered to take part in these clinical trials to help find improvements in fighting cancer with proton therapy.
With SCCA, our team has made a commitment to participate in clinical trials to further our knowledge of the benefits of proton therapy in many tumor types.

People helping people

Clinical trials are research studies that invite people to participate in the final step in a long process that begins with research in a lab. Each study answers a specific set of scientific questions and explores better ways to prevent, screen for, diagnose or treat a disease. Most treatments used today are the results of past clinical trials. Clinical trials are used even after treatments are approved for use, to help answer additional questions. SCCA Proton Therapy has a registry trial open to all proton therapy patients.

Protocols help us find solutions

For every clinical trial, a protocol, or action plan, is prepared prior to conducting the trial. The protocol describes in detail what will be done in the study, how it will be conducted, and why each part of the study is necessary. Each study has its own rules about who can participate. For instance, some studies need patients with a certain condition, some need healthy people, some need just men or just women, etc.

Your participation can make a difference

Clinical trials are carefully controlled research studies done with patients who volunteer. There are many requirements you must meet to be part of a study. If you qualify, it is up to you whether to take part.
Not all patients are cured with standard therapy, and some standard treatments may have side effects that patients and doctors would prefer to avoid, if possible. So patients may seek help through clinical studies. Patients who participate in studies have the first chance to benefit from treatments that have shown promise in earlier research. They also make an important contribution to medical science by helping doctors learn more about the disease and potential new treatments.

Featured Clinical Trials

Access Breakthrough Treatments. Improve Care to Others.

A critical part of the mission at our partner Seattle Cancer Care Alliance (SCCA) is to bring promising new treatments to patients faster. Patients who participate in clinical studies often have the first chance to benefit from treatment approaches that have shown promise in earlier research.

Proton therapy’s efficacy in treating many types of cancer has been well established, but many questions remain unanswered. Our clinical studies hope to make an important contribution to medical science by helping doctors learn more about how effective proton therapy is in treating cancer when compared with other forms of radiation therapy, and when used in combination with other treatments such as chemotherapy and surgery. We also intend to examine outcomes for patients who receive the higher radiation doses made possible by this precise technology.

FLARE RT for Patients With Stage IIB-IIIB Non-small Cell Lung Cancer: Personalizing Radiation Therapy Using PET/CT and SPECT/CT Imaging Jing Zeng, MD Lung Cancer NCT02773238 Learn More
Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial Justin Bekelman, MD Breast Cancer NCT02603341 Learn More
Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC Ramesh Rengan, MD Lung Cancer NCT01993810 Learn More
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Lia Halasz, MD CNS: Glioblastoma NCT02179086 Learn More
Pediatric Proton Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients treated with Proton Radiation Therapy Ralph Ermoian, MD Childhood Cancers NCT01696721 Learn More
Proton Therapy vs. IMRT for Low or Intermediate Risk Prostate Cancer (PARTIQoL) Jing Zeng, MD Prostate Cancer NCT01617161 Learn More
Evaluation Tracking Project: A Prospective Chart Review of Patients Treated With Proton Therapy George Laramore, MD Solid Tumors NCT01255748 Learn More
Pulmonary Functional Imaging for Radiation Treatment Planning for Lung Cancer Jing Zeng, MD Lung Cancer NCT01982123 Learn More
Definitive Re-Irradiation With Proton Beam Radiotherapy for Patients With Recurrent Thoracic Cancers Jing Zeng, MD Lung Cancer NCCT02204761 Learn More
Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma George Laramore, MD CNS: Recurrent Glioblastoma NCT01730950 Learn More
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 Years Amy A Smith, MD Childhood: Ependymoma NCT01096368 Learn More
A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma Doug Hawkins, MD Childhood: Ewing Sarcoma NCT01231906 Learn More
Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT) Doug Hawkins, MD Childhood: CNS Germ Cell Tumors NCT01602666 Learn More
A COG Pilot Study of Intensive Induction Chemotherapy and 131I-MIBG Followed by Myeloablative Busulfan/Melphalan (Bu/Mel) for Newly Diagnosed High-Risk Neuroblastoma Brian Weiss, MD Childhood: Neuroblastoma NCT01175356 Learn More

Featured Studies

Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy Sethi RV, Shih HA, Yeap BY, Mouw KW, Petersen R, Kim DY, Munzenrider JE, Grabowski E, Rodriguez-Galindo C, Yock TI, Tarbell NJ, Marcus KJ, Mukai S, Macdonald SM. Read Study
An in-silico comparison of proton beam and IMRT for postoperative radiotherapy in completely resected stage IIIA non-small cell lung cancer Berman AT, Teo BK, Dolney D, Swisher-McClure S, Shahnazi K, Both S, Rengan R. Read Study
Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients. Shannon M. MacDonald, Roshan Sethi, Beverly Lavally, Beow Y. Yeap, Karen J. Marcus, Paul Caruso, Margaret Pulsifer, Mary Huang, David Ebb, Nancy J. Tarbell, and Torunn I. Yock Read Study
Accelerated partial-breast irradiation using intensity-modulated proton radiotherapy: do uncertainties outweigh potential benefits? Wang X, Zhang X, Li X, Amos RA, Shaitelman SF, Hoffman K, Howell R, Salehpour M, Zhang SX, Sun TL, Smith B, Tereffe W, Perkins GH, Buchholz TA, Strom EA, Woodward WA. Read Study
A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma Abei M, Okumura T, Fukuda K, Hashimoto T, Araki M, Ishige K, Hyodo I, Kanemoto A, Numajiri H, Mizumoto M, Sakae T, Sakurai H, Zenkoh J, Ariungerel G, Sogo Y, Ito A, Ohno T, Tsuboi K. Read Study
Initial Report of Pencil Beam Scanning Proton Therapy for Posthysterectomy Patients With Gynecologic Cancer. Lin LL, Kirk M, Scholey J, Taku N, Kiely JB, White B, Both S Read Study